keyboard shortcuts not working

I have two AutoLISP applications using AutoCAD 2014.  Both have a custom menu.  In each there are keyboard shortcuts defined.  In one application the shortcuts work and in the other they do not.

For example, in the application that does not work and Ctrl-C is a cancel.  Ctrl-O is a Ortho toggle.  But, they should be, per CUI for that application, Copy Clip and Open.

I know these are the OLD AutoCAD definitions of these keyboard shortcuts.  Any idea why I should the shortcuts to work in one and not in the other?  Pickfirst is set to 1 in both.

Thanks.

Image may be NSFW.
Clik here to view.Image may be NSFW.
Clik here to view.Image may be NSFW.
Clik here to view.Image may be NSFW.
Clik here to view.Image may be NSFW.
Clik here to view.

Image may be NSFW.
Clik here to view.